Genetic testing has become a crucial tool in modern medicine to diagnose inherent disorders, guide personalized treatments, and predict an individual’s risk of developing certain conditions. Automated microscopy enables high-throughput analysis of specific chromosomal abnormalities in cells using fluorescence in situ hybridization (FISH). In addition, high-quality optics and advanced imaging capabilities allow for combined cell morphology examination to FISH analysis can be combined with morphology examination to increase the sensitivity and specificity of an assay, leading to better patient outcomes.